menB [2019-06-25 09:24:46]

naphthoate synthase

Locus: BSU30800

Isoelectric point: 5.34

Molecular weight: 29.75 kDa

Protein length: 271 aa

Gene length: 816 bp

Function: biosynthesis of menaquinone

Product: naphthoate synthase

Essential: yes

E.C.: 4.1.3.36

Synonyms

Genomic Context

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Categories containing this gene/protein

• Metabolism → Additional metabolic pathways → Biosynthesis of cofactors → Biosynthesis of menaquinone
• Groups of genes → Essential genes
• Groups of genes → Phosphoproteins → Phosphorylation on an Arg residue

Gene

Coordinates: 3,148,901 3,149,716

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• o-succinylbenzoyl-CoA = CoA + 1,4-dihydroxy-2-naphthoate (according to Swiss-Prot)

Protein family

• enoyl-CoA hydratase/isomerase family (according to Swiss-Prot)

Modification

• phosphorylated on Arg-78 and Arg-269 PubMed

Structure

• 1RJM (from Mycobacterium tuberculosis, 48% identity, 61% similarity)

Expression and Regulation

Operons

• Genes: menB-menE-menC
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Additional information

  • A ncRNA is predicted between 'mntA' and 'menC' PubMed

• Genes: menF-menD-ytxM-menB-menE-menC
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Additional information

  • A ncRNA is predicted between 'mntA' and 'menC' PubMed

References

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